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Although discussions of atherosclerosis normally focus on the guts, the disease can and often does affect arteries throughout your physique. When it happens within the arteries supplying blood to your limbs, it causes peripheral artery disease. Peripheral artery illness is usually caused by atherosclerosis. In atherosclerosis, fatty deposits build up in your artery walls and cut back blood circulate. If peripheral artery disease progresses, ache could even happen whenever you’re at rest or if you’re lying down.